Effect of individualised homoeopathic intervention in dyslipidaemia: An open-label, randomised, controlled, exploratory trial

Authors

Roja Varanasi, Central Council for Research in Homoeopathy, New Delhi, IndiaFollow
Rupali Bhalerao, Central Council for Research in Homoeopathy, New Delhi, IndiaFollow
Raveendar Ch, Regional Research Institute for Homoeopathy, Gudivada, Andhra Pradesh, IndiaFollow
Raju Kolli, Homoeopathy Research Institute for Disabilities, Chennai, Tamil Nadu, IndiaFollow
Ravi Sardala, Homoeopathy Research Institute for Disabilities, Chennai, Tamil Nadu, IndiaFollow
R.V.R. Prasad, Clinical Research Unit (T), Tirupati, Andhra Pradesh, IndiaFollow
Paul Sumithran, National Homoeopathy Research Institute in Mental Health, Kottayam, Kerala, IndiaFollow
M. Prakash Rao, Clinical Research Unit for Homoeopathy, Puducherry, IndiaFollow
Ramesh Dubashi, Regional Research Institute for Homoeopathy, Hyderabad, Telangana, IndiaFollow
Kiranmayee R.G.R, Regional Research Institute for Homoeopathy, Hyderabad, Telangana, IndiaFollow
S. Rajeeva, Regional Research Institute for Homoeopathy, Gudivada, Andhra Pradesh, IndiaFollow
V. Sarathy, Homoeopathy Research Institute for Disabilities, Chennai, Tamil Nadu, IndiaFollow
P.A. Rajakumari, Clinical Research Unit (T), Tirupati, Andhra Pradesh, IndiaFollow
Priyanka Srivastava, Central Council for Research in Homoeopathy, New Delhi, IndiaFollow
Anupriya Chaudhary, Central Council for Research in Homoeopathy, New Delhi, IndiaFollow
Gnnana Prakasham, National Homoeopathy Research Institute in Mental Health, Kottayam, Kerala, IndiaFollow
P. Prasad, Homoeopathy Research Institute for Disabilities, Chennai, Tamil Nadu, IndiaFollow
Arvind Kumar, Central Council for Research in Homoeopathy, New Delhi, IndiaFollow
Viqar A. Siddiqui, Central Council for Research in Homoeopathy, New Delhi, IndiaFollow
Praveen Oberai, Central Council for Research in Homoeopathy, New Delhi, IndiaFollow
Raj K. Manchanda, Central Council for Research in Homoeopathy, New Delhi, IndiaFollow

Author ORCID Identifier(s)

https://orcid.org/my-orcid?orcid=0000-0001-9475-0037

Corresponding Author

Roja Varanasi

Keywords

Dyslipidaemia, Individualised Homoeopathy, Lifestyle modification, Therapeutic lifestyle changes.

Article Type

Original Article

Abstract

Background: Dyslipidaemia, the derangement of one or many of the lipoproteins is a major cause of cardiovascular events, causing 2.6 million deaths per year globally.

Objectives: This study evaluated the efficacy of individualised homoeopathic medicines with lifestyle modification in the management of dyslipidaemia.

Materials and Methods: This multicentric, open-label, randomised controlled exploratory trial was conducted at seven study sites under the Central Council for Research in Homoeopathy. Participants fulfilling the eligibility criteria were enrolled. The primary outcome was to evaluate changes in Low-Density Lipoprotein cholesterol at months 3 and 6. Secondary outcomes were to evaluate changes in total cholesterol, triglyceride, and high-density lipoprotein at months 3 and 6.

Results: All pre-determined study outcomes followed the intention-to-treat approach. 217 patients (Individualised Homoeopathy (IH) along with lifestyle modification (IH plus therapeutic lifestyle changes [TLC]) n = 107; Placebo along with TLC (n = 110) were enrolled and analysed. Independent t-test at month 6 showed a statistically significant reduction in LDL (mean difference ± standard error: 7.03 ± 3.3; 95% confidence interval = 0.5–13.5; p = 0.03) favouring IH over placebo. Improvement in secondary outcomes; reduction in total cholesterol (p > 0.05) and triglycerides (p > 0.05) was greater in the IH group but was statistically insignificant (p > 0.05). Associated symptoms such as rheumatological and neurological complaints also improved in the IH group. Frequently prescribed medicines were Lycopodium, Sulphur, and Calcarea carbonica.

Conclusion: IH along with lifestyle modification was found to play a potential role in reducing the LDL cholesterol and in the management of dyslipidaemia. Further blinded studies in different settings and long-term follow-up are warranted.

Digital Object Identifier

10.53945/2320-7094.2027

Publisher

Central Council for Research in Homoeopathy

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

How to cite this article

Varanasi R, Bhalerao R, Ch R, et al. Effect of individualised homoeopathic intervention in dyslipidaemia: An open-label, randomised, controlled, exploratory trial. Indian J Res Homoeopathy 2025;19:15-24. doi: 10.53945/2320-7094.2027