An in vitro comparative assessment of antidiabetic efficacy: Abroma augusta Q, Gymnema sylvestre Q, Cephalandra indica Q, Momordica charantia Q, Syzygium jambolanum Q in comparison to Metformin

Authors

Mary Adharshna S.P., Vinayaka Mission's Research Foundation (Deemed To Be University), Salem, Tamil Nadu, IndiaFollow
Vettrivel Arul, Vinayaka Mission's Research Foundation (Deemed To Be University), Salem, Tamil Nadu, IndiaFollow

Author ORCID Identifier(s)

Mary adharshna SP:- https://orcid.org/0000-0002-7489-1796

Vettrivel Arul:- https://orcid.org/0000-0002-2319-726X

Corresponding Author

S.P. Mary Adharshna

Keywords

α-amylase, α-glucosidase, Anti diabetic, Diabetes, Homoeopathy, In vitro, Mother tinctures

Article Type

Original Article

Abstract

Background: Homoeopathic mother tinctures are gaining attention for managing diabetes by inhibiting key enzymes in glucose metabolism.

Objective: This study aimed to compare popular homoeopathic mother tinctures Abroma augusta Q (AAQ), Cephalandra indica Q (CIQ), Gymnema sylvestre Q (GSQ), Momordica charantia Q (MCQ) and Syzygium jambolanum Q (SJQ) with Metformin (MET) in inhibiting diabetes associated α-amylase and α-glucosidase enzymes.

Methods: Mother tinctures AAQ, CIQ, GSQ, MCQ, SJQ and MET of concentrations 10 μL/mL, 50 μL/mL, 100 μL/mL, 250 μL/mL, and 500 μL/mL were assessed through α-amylase and α-glucosidase inhibitory assay.

Results: All mother tinctures show significant inhibitory action at p < 0.01. AAQ and GSQ exhibited potent inhibition of both enzymes, with inhibitory percentages ranging from 70.41% (500 μL/mL) to 58.98% (10 μL/mL) for α-amylase and 68% (500 μL/mL) to 43.72% (10 μL/mL) for α-glucosidase and 73.98% (500 μL/mL) to 63.66% (10 μL/mL) for α-amylase and 65.31% (500 μL/mL) to 25.99% (10 μL/mL) for α-glucosidase, respectively. AAQ has an IC50 value of 107.9 μL/mL (α-amylase) and 43.87 μL/mL (α-glucosidase) which makes it evidently, a potent antidiabetic mother tincture.

Conclusion: AAQ and GSQ demonstrated significant inhibition of diabetes associated enzymes when compared with MET.

Digital Object Identifier

10.53945/2320-7094.1941

Publisher

Central Council for Research in Homoeopathy

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

How to cite this article

Adharshna SP, Arul V. An in vitro comparative assessment of antidiabetic efficacy: Abroma augusta Q, Gymnema sylvestre Q, Cephalandra indica Q, Momordica charantia Q, Syzygium jambolanum Q in comparison to Metformin. Indian J Res Homoeopathy 2024;18:228-235.